Research Fellow (78133-066)

Vacancy Type/Job category

Research Only

Department Warwick Medical School, Metabolic and Vascular Health
Salary £28,982 - £37,768 per annum
Location University of Warwick, Coventry

 

Vacancy Overview

Fixed term Research fellowship contract for 12 months, with optional extension for a further 12 months.

Applications are invited from motivated biomedical scientists to undertake research in the field of experimental chronopharmacoloy and chronotherapy of cancer.

You will work with Professor Francis Lévi, and his close collaborators, Dr Pasquale Innominato and Dr Robert Dallmann, in the Cancer Chronotherapy Unit. You will address pending issues in molecular and cellular cancer chronotherapeutics research, focussing on gastro-intestinal malignancies. Your research will combine studies in synchronized healthy and cancer cells both at cell population and at single cell levels, as well as in mice, in order to jointly enhance tolerability and antitumour efficacy of anticancer drugs through circadian scheduling of combination therapies.

The WMS Cancer Chronotherapy team at Warwick has tight links with the Chemistry, the Systems Biology and the Statistics Department, with funded research and activities by the MRC, Cancer Research UK, the European Commission (FP7), and has just been acknowledged as a European Associated Laboratory by INSERM (Institut National de la Sante et de la Recherche Medicale in France). Our team has further broad international collaborations, both at experimental and clinical levels.

You will identify, select, and modify a battery of existing or available healthy and cancer cell lines for your project (liver, pancreas, colon,,..), so as develop experimental studies on malignant and non-malignant models, in conjunction with Professor Levi’ lab and Professor Rand’s Systems Biology Centre (SB). You will design these studies through following SB approaches to the reciprocal interactions between the Circadian Timing System, cellular proliferation and anticancer drug metabolism. The drugs of interest are in the cytostatic and the therapeutic targeted agents domains, and will be selected with you, according to ongoing programs in the Unit. Among other drugs, you will be working with novel metallic compound drugs and nanoparticles through a collaborative project involving the Chemistry Department at Warwick and funded by Cancer Research UK. The work involves the use of molecular biology, physiology, pharmacology, and imaging in cells and mice, under your responsibility, as well as dedicated statistical, bioinformatics and mathematical methods whenever appropriate, which will be provided by SB if needed.

You will be expected to deliver excellent research outputs. You will possess a PhD in biomedical sciences (or will hold equivalent European qualification by examination) and a few related publications in international journals which demonstrate your ability to conduct a research project in circadian and/or cancer pharmacology and therapeutics on your own.

Where you have not yet been awarded your PhD, any offer made to you will be an under-appointment to the post of Research Assistant at a salary of £28,143. Upon successful award of your PhD and evidence of this fact, you will be promoted to Research Fellow at level 6 and with a salary within the range stated above.

Job Description

JOB PURPOSE:

To undertake research in order to support the work of the department and develop and enhance its reputation, both internally and externally. Assist the Project Leader and, where appropriate, project collaborators in the successful execution of the project.

DUTIES AND RESPONSIBILITIES:

Research and scholarship

  1. Help establish a sound research base within the Cancer Chronotherapy Unit, and the several component of the WMS department, in order to assist the development of research objectives and proposals for own or joint research.
  2. Conduct individual and collaborative research projects on cancer chronotherapeutics.
  3. Write up research work for publication.
  4. Translate knowledge of advances in the subject area into research activity.
  5. May contribute to preparing proposals and applications to external bodies, e.g. for funding and contractual purposes, to support a developing research agenda.
  6. May present information on research progress and outcomes to bodies supervising research, e.g. steering groups.
  7. May contribute to the preparation of papers for steering groups and other bodies.
  8. Communicate complex information (orally and in writing) and material of a specialist or highly technical nature.
  9. Continually update own knowledge and understanding in field or specialism.

Teaching and Learning Support

  1. Could be expected to contribute to the teaching and learning programmes in the department.
  2. Assist in the supervision of student projects and the development of student research skills.
  3. May be involved in the assessment of student knowledge and supervision of projects.

Administration and Other Activities

  1. May be required to attend departmental meetings and to participate (where necessary) in other committees and working groups within the department, the faculty and the University.
  2. Ensure compliance with health and safety in all aspects of work.
  3. Work within budget constraints.

Person Specification

The Person Specification focuses on the knowledge, skills, experience and qualifications required to undertake the role effectively. This is measured by (a) Application Form, (b) Test/Exercise, (c) Interview, (d) Presentation.
Essential Criteria 1 Good honours degree and possession of a PhD in biomedical sciences (or equivalent European qualification by examination) or equivalent in relevant discipline. (a)
Essential Criteria 2 Proven ability in research and evidence of quality research output in molecular and cellular cancer chronobiology, and/or chronopharmacology, or relevant discipline. (a)(c)(d)
Essential Criteria 3 A developing research profile with the ability to publish and/or produce high quality research output. (a)(c)
Essential Criteria 4 Sufficient breadth or depth of specialist knowledge in molecular biology, mouse physiology, pharmacology, and imaging in cells, and of research methods and techniques to work within established research programmes. (a)(c)
Essential Criteria 5 Ability or potential to contribute to the development of funding proposals in order to generate external funding to support research projects. (a)(c)
Essential Criteria 6 Excellent presentation and interpersonal skills. Ability to work well in a research team and independently as needed. (a)(c)
Essential Criteria 7 Ability to communicate complex information (orally and in writing) and material of a specialist or highly technical nature. (a)(c)
Essential Criteria 8 An understanding of equal opportunity issues as they may impact on areas of research content. (a)(c)
Desirable Criteria 1 Previous research involving imaging and/or cell specific genetic reporters. (a)(c)(d)
Desirable Criteria 2 Previous experience in generating and employing viral vectors (a)(c)(d)
Desirable Criteria 3 Previous involvement in research on circadian clocks or in vitro pharmacology (a)(c)(d)
Desirable Criteria 4 Previous research involving in vivo procedures (a)(c)(d)
Desirable Criteria 5 Possession of a UK Home Office Personal Licence, or evidence of up to date Modules 1-4 training. Ability or potential to contribute to the development of funding proposals in order to generate external funding to support research projects. (a)(c)
Further Particulars For further information about the University of Warwick, please read ourUniversity Further Particulars.
Recruitment of Ex-Offenders Policy As an organisation using the (DBS) Disclosure and Barring Service to assess applicants’ suitability for positions of trust, the University of Warwick complies with the DBS Code of Practice and undertakes not to discriminate unfairly against any subject of a Disclosure on the basis of a conviction or other information revealed. More information is available on the University’s Vacancy pages and applicants may request a copy of the DBS Code of Practice.
Closing Date 28 Jun 2016